KETAFUR 100 ML

Product Description

COMPOSITION

1 ml of the drug contains active ingredients:

ceftiofur hydrochloride – 50 mg;

ketoprofen – 150 mg.

Excipients: benzyl alcohol, butylhydroxyanisole, butylhydroxytoluene, propylene glycol dicaprylate/dicaprate, sorbitan oleate (SPAN 80).

PHARMACOLOGICAL PROPERTIES

ATC-vet classification code: QJ01 – antibacterial veterinary drugs for systemic use. QJ01DD99 – ceftiofur, and combinations.

Ceftiofur is a broad-spectrum antibiotic of the cephalosporin group 3rd generation, it is active against β-lactamase producing bacteria and some anaerobes, including Gram-positive (Staphylococcus spp., Actinomyces pyogenes, Streptococcus spp., Bacillus spp.) and Gram-negative bacteria (Escherichia coli, Pasteurella (Mannheimia) haemolytica, Pasteurella multocida, Haemophilus somnus, Actinobacillus pleuropneumoniae, Pasteurella spp., Salmonella typhimurium, Klebsiela spp., Citrobacter spp., Enterobacter spp., Proteus spp., Fusobacterium necrophorum,Porphyromonas asaccharolytica (Bacteroides melaninogenicus)), which leads to disruption of the osmotic balance and destruction of their cells.

After parenteral administration, it is metabolized to form desfuroylceftiofur, which accounts for most of ceftiofur antimicrobial activity. This metabolite binds reversibly to plasma proteins and accumulates in the focus of inflammation.

After a single intramuscular injection at a dose of 1 mg/kg b.w. peak plasma concentrations of ceftiofur and desfuroylceftiofur are reached within five hours. The half-life of ceftiofur and its metabolites is approx. 22 hours.

Ketoprofen is a derivative of propionic acid from the group of carboxylic acids; it has analgesic and antipyretic effects. The mechanism of ketoprofen action is to inhibit the enzyme cyclooxygenase and inhibit the synthesis of prostaglandins and thromboxane. The analgesic effect of ketoprofen is associated with the inhibition of bradykinin itself, which excites pain nerve endings and thereby provokes pain.

Ketoprofen acts on the central nervous system, suppressing the perception of pain.

After intramuscular administration, it is rapidly absorbed. More than 98% of ketoprofen binds to plasma proteins and is concentrated in inflamed tissues. The maximum plasma concentration is reached within four hours. The half-life is about four hours.

INDICATIONS

KETAFUR is indicated for the treatment of necrobacteriosis and endometritis in cattle, as well as respiratory diseases accompanied by fever and pain, caused by microorganisms susceptible to ceftiofur.

ROUTE OF ADMINISTRATION AND DOSAGE

Intramuscularly once a day at a dose of 1 ml per 50 kg of animal body weight (1 mg of ceftiofur and 3 mg of ketoprofen per 1 kg of animal body weight).

The course of treatment is: for respiratory diseases – 3-5 days, for necrobacteriosis – 3 days, for endometritis – 5 days.

CONTRAINDICATIONS

Do not use in cases of known resistance to ceftiofur or other cephalosporins and beta-lactam antibiotics.

Do not administer to animals with hypersensitivity to ceftiofur and other beta-lactam antibiotics or excipients.

Do not use in animals under 6 weeks of age.

Do not use in animals with impaired hematopoiesis, ulcers of the gastrointestinal tract, or kidney and liver diseases.

Do not administer to animals in a state of hypotension, hypovolemia and dehydration.

The use of the drug during lactation is not prohibited.

Do not use simultaneously and within 24 hours with other non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticosteroids, diuretics, and anticoagulants.

Do not use simultaneously with tetracyclines, chloramphenicol, macrolides, and lincosamides.

PRECAUTIONS

The use of ceftiofur should be based on an antimicrobial susceptibility study. Do not use if ceftiofur-resistant strains of pathogenic bacteria are found.

The drug is not recommended to be mixed in the same syringe with other drugs.

Shake the bottle thoroughly before use.

WITHDRAWAL PERIOD

Slaughter of animals for meat is allowed 8 days after the last use of the drug. Milk consumption is allowed without restrictions.

PACKAGE AND PRESENTATION

Glass bottles or made of polymeric materials, 10, 50, 100, 200, 250 ml.

STORAGE CONDITIONS

In a dark place, out of the reach of children at a temperature of 5°C to 25°C.

SHELF LIFE

24 months.

After the first withdrawal of the drug from the vial, it must be used within 28 days, if stored in a dark place at a temperature of 5°C to 25°C.