CLAMOXAN 100 ML

Product Description

COMPOSITION

1 ml of the preparation contains the following active substances:

Amoxicillin (as Amoxicillin Trihydrate) – 140 mg;

Clavulanic acid (as Potassium clavulanate) – 35 mg.

Excipients.

PHARMACOLOGICAL PROPERTIES

Amoxicillin is a semi-synthetic antibiotic of penicillin group. It blocks the synthesis of bacterial cell walls, inhibits enzyme activity of transpeptidase and carboxypeptidase, and causes violations of osmotic balance that leads to death of pathogens at stage of development. Amoxicillin has wide bactericidal action and is active against Gram-positive and Gram-negative bacteria such as: Staphylococcus spp., Streptococcus, spp. (S.agalactiae, S.dysgalactiae, S.uberis), E.coli, Arcanobacteria (incl. A.pyogenes), Corynebacteria spp., Clostridia spp, Bacillus anthracis, Actinomyces bovis, Bacillus cereus, Bacteroides(incl. strains, producing β-lactamase), Campilobacter spp., Klebsiella spp, Pasteurella spp., Escherichia coli, Salmonella spp., Proteus spp., Fusobacterium necrophorum, Haemophilus spp., Moraxella spp., Actinobacillus lignieresіi.

Clavulanic acid is one of the natural metabolites of Streptomyces clavuligerus. It resembles penicillin in a structurally similar nucleus with a β-lactam ring. Clavulanic acid is an inhibitor of the β-lactamase enzyme, the action of which is initially active, and ultimately passes the inactivation. Clavulanic acid penetrates the bacterial cell wall and binds external and intracellular β-lactamase enzymes.

Amoxicillin in combination with an inhibitor of this enzyme (clavulanic acid) broadens the spectrum of antimicrobial activity.

After parenteral injection, the product is rapidly absorbed and distributed throughout the tissues of the body, reaching high concentrations in muscle tissues, liver, and kidneys.

TARGET ANIMALS

Cattle, pigs.

INDICATIONS

Treatment of cattle, pigs with diseases of the respiratory system (bronchitis, bronchopneumonia, rhinitis), urogenital system (metritis, endometritis, cystitis, urethritis, pyelonephritis), joints, skin and soft tissues (umbilical infections, wounds, abscesses, inflammations), as well as treatment of animals with leptospirosis, mastitis, agalactia in pigs, actinomycosis, erysipelas of pigs, parainfluenza and paratyphoid, caused by pathogens susceptible to Amoxicillin and Clavulanic acid.

ADMINISTRATION AND DOSAGE

Intramuscularly 1.0 ml per 20 kg body weight once a day for 3-5 days.

Before application, the preparation should be shaken thoroughly. Use only dry syringes and needles to draw out the product. Before drawing out, wipe the cap with a tissue moistened with antiseptic solution. After the injection, do the massage at the injection site.

WITHDRAWAL PERIOD

Meat is allowed for consumption in 42 days after last treatment. Milk for human consumption is allowed in 60 hours after last treatment. Meat and milk received before this time should be disposed or fed to non-productive animals, depending on conclusion of veterinarian.

SHELF LIFE

24 months. After first opening: 28 days if kept in dark place at +5° to +25°С.

STORAGE CONDITIONS

Store in dark place, out of the reach of children at +5° to +25°С.